奋发向上的医学院学生宝拉（FrankaPotente），好不容易获准进入颇负盛名的海德堡研究机构，她希望能继承祖父的衣钵，成为一名出色的医生。在上解剖课时，她发现解剖台上的尸体竟是她认识的人，便积极暗中调查尸体的来源，发现有一个以残酷手法研究活人的神秘社团在学校活动，而班上的同学也一一离奇失踪，她决定继续挖掘真相。
A clever fortune-hunter with a penchant for murder does in his elderly, supposedly rich, wife and manages to get away with it. After an investigation results in a decision of 'accidental death', our crafty killer discovers that his late wife's 'fortune' is not what he thought it was. Driven to find another unsuspecting spouse; he discovers that his new bride, a widow, is no fool. When she tells him that she intends to keep her accounts separate from his, he is driven to contemplate murder once again
根据斯蒂芬·金小说改编，某天女主角杰西和丈夫杰罗德到乡村别墅度假，丈夫突发奇想要玩一个疯狂的性游戏，结果心脏病突发死亡，而杰西则还被铐在床头不能动弹，面对杰罗德尸体被野狗一块块撕嚼，杰西必须想法脱身
